The world mechanical ventilation market is estimated at $3.2B with the US representing the largest geographic market. There are eight major manufacturers of mechanical ventilators, all of them actively competing for market share. As an accessory product business model, Nespiro’s market is an estimated $192M in the US on disposable components alone. However, Nespiro’s technology has a higher value proposition as an integrated product through market share dynamics; a 1% shift in global market share is worth $32M. Three of the eight major manufacturers currently do not have a weaning technology and Nespiro has already been identified as an acquisition target for CareFusion’s Respiratory Solutions’ roadmap for growth.